Maider Uriarte San Martin

Analysis of the KRAS gene: Implications for cancer and targeted therapies.

Started Apr. 9, 2024

Abstract or project description

The KRAS gene has been identified as a crucial player in cancer development and progression, which has catalyzed a research project focused on unraveling its complex interactions and therapeutic potential. In my research, I will explore several facets of the KRAS gene and its relevance in cancer, without performing direct experiments. First, I will analyze in detail the mutations of the KRAS gene. This will include the identification and classification of the different variant mutations present in different types of cancer, as well as their frequency and distribution in the population. In addition, I will examine how these mutations affect normal cellular functions, which may provide crucial information on the mechanisms underlying KRAS-induced carcinogenesis. Second, I will investigate the molecular mechanisms of KRAS oncogenicity. This involves understanding the intracellular signaling pathways activated by KRAS mutations and how these contribute to cancer development and progression. I will also explore the interaction networks between mutant KRAS and other cellular proteins, as well as the regulation of gene expression induced by KRAS mutations, which may shed light on new potential therapeutic targets. Finally, I will discuss the therapeutic implications of KRAS mutations. This will include evaluating the efficacy of KRAS inhibitors in development for the treatment of different cancers with mutations in this gene. In summary, my research will address fundamental aspects of the KRAS gene in cancer, from the characterization of its mutations to therapeutic implications, without performing direct experiments, but through a thorough review and analysis of the available scientific literature.