Shreya Srikanth

Reviewing candidate genes for skeletal class III malocclusion.

Started June 1, 2023

Abstract or project description

Class III skeletal malocclusion, a complex craniofacial disorder characterized by an anterior crossbite due to mandibular prognathism or maxillary retrognathism, poses significant challenges in orthodontics and craniofacial genetics.With a suspected genetic component underlying its etiology, it’s important to be able to understand the specific candidate genes and their functional significance in Class III malocclusion. This research aims to unravel the genetic basis of Class III skeletal malocclusion by identifying key candidate genes and assessing their potential roles in the condition. The research investigates the genetic basis of Class III skeletal malocclusion, a complex craniofacial disorder causing anterior crossbite. Despite its prevalence and impact on individuals' well-being, the precise genetic mechanisms remain elusive. We aim to identify candidate genes associated with Class III malocclusion, exploring their spatial and temporal expression patterns during critical developmental stages. Regulatory network analysis will unveil potential gene interactions and shared pathways contributing to the condition. Understanding these specific genetic factors could revolutionize craniofacial genetics, precision orthodontics, and personalized treatment strategies, enhancing the quality of life for individuals with Class III malocclusion. The findings from this study may pave the way for advancements in craniofacial genetics, precision orthodontics, and personalized treatment modalities, ultimately benefiting individuals with Class III malocclusion and improving their quality of life. By understanding the specific genetic factors contributing to this condition, our research aims to provide valuable insights that can advance the field of orthodontics and craniofacial genetics, leading to more effective and personalized treatment strategies for individuals with Class III skeletal malocclusion.