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Browse project ideas by Polygence mentors
Exploring CRISPR: The Gene Editing Revolution
In this project, students will dive into the world of CRISPR, a groundbreaking gene-editing technology that has transformed the field of genetics. Students will explore how CRISPR works, its scientific discoveries, and the wide range of applications—from curing genetic diseases to improving agriculture. They will also examine ethical questions and real-world case studies to understand both the potential and the challenges of using this technology. By reading scientific articles, watching videos, and conducting guided research, students will gather information and write a review-style research article summarizing what CRISPR is, how it’s being used today, and what the future might hold. This project is designed to strengthen science communication skills while encouraging curiosity about genetics and biotechnology.
Creative Writing, Ethics, Biology
Local Concentration at the Nanoscale
We can examine how local concentrations at the nanoscale influence the collective behavior of various systems and mimic how an axon fires a signal.
Math, Physics, Chemistry
A Burning State: California’s Complicated Relationship with Fire
California burns—literally and metaphorically. From the towering infernos of the Sierra Nevada to the dry chaparral of the coast, fire has long shaped California’s landscapes, communities, and policies. But the story of fire in the Golden State is more than just one of devastation—it's a story of decisions, history, suppression, and resilience. This project invites students to explore California’s complex relationship with fire, past and present. Whether you're passionate about environmental law, public policy, or history, this is your chance to dig into one of the most urgent and misunderstood environmental issues of our time. We’ll examine how the state’s legacy of fire suppression—including the banning of Indigenous controlled burn practices—has contributed to the dangerous buildup of biomass in our forests today. We’ll also look at how recent events like the Palisades Fire of January 2025 have reignited debates around ecological stewardship and the need for proactive, historically informed fire policy. Students can tailor their focus to their interests: analyze how California industries (from timber to tech) have intersected with fire over time, explore the rise of the bioeconomy as a tool for fire mitigation, or conduct archival research on how state and federal fire policies evolved over the 20th and 21st centuries. This is more than a research project—it's a chance to turn the embers of curiosity into sparks of understanding. Let’s study fire not just as a threat, but as a mirror of California’s environmental past and a map for its more resilient future.
Social Science
Science of Skincare & Dermatology: From Ingredients to Marketing
I would love to help students explore The Science of Skincare, where we can dive deep into what really goes into the products we put on our skin—and why it varies so much across the globe. From decoding ingredient labels to exploring the biology of your skin, students will uncover the chemistry, culture, and regulations behind skincare in the U.S. and Europe. Along the way, they'll compare beauty standards, marketing trends, and health impacts, while learning to make informed choices about the products they use every day. This is where science meets self-care—with a global twist.
Cancer, Biology, Chemistry
Application of GenerativeAI - Commoditizing Intelligence
The recent growth of reasoning models (ChatGPT o3, Gemini 2.5 Pro, Claude 3.7 Thinking, DeepSeek R1) has enabled highly reliable reasoning applied to highly generalized problems. This enables business to rearchitect workflows and systems that can flexibly handle variability in ways that traditional systems could not.
Engineering, Business
Can We Make Brain Scans from Different Hospitals Look More Similar?
When scientists use brain scans (like MRIs) from different hospitals, the images can look a little different because they were taken with different machines. This can confuse computer programs that are trying to learn patterns, like figuring out who might have a disease based on their brain scan. In this project, you'll explore how we can make these scans look more similar—this process is called harmonization. You’ll learn how to use AI tools like convolutional neural networks (CNNs), which are great at looking at images, and generative AI methods like GANs (generative adversarial networks), which can help transform one type of image to look like another. You’ll also explore domain adaptation methods—these help AI models adjust when the data comes from different places. The goal is to teach the computer to ignore the differences between scanners and focus on what’s really important: the patterns in the brain that relate to health. This is a great way to dive into machine learning, computer vision, and real-world healthcare problems using brain imaging data.
AI/ML
Advancements at the Intersection of AI and Aerospace Science
This research project aims to explore the transformative role of artificial intelligence (AI) in aerodynamics and highlight its profound impact on the field. It examines how AI algorithms are revolutionizing traditional methods of aerodynamic analysis and design, allowing for more efficient and optimized aircraft configurations. The project delves into specific applications such as airfoil design, where AI decreases the time to results with the design of the experiment. It also explores the challenges that come along with linking AI with aerospace whether that be the guidance, navigation, and control issues or the long-term sustainability and efficiency of current commercial systems.
AI/ML, Engineering, Computer Science, Business
Field Survey Proposal for: Building an Eco-Friendly Multipurpose Stadium/
The project’s primary aim is to coduct a study on multipurpose dome for football, among other uses, while adhering to sustainable practices. We aimed to align this project with Saudi Arabia’s national goals of reducing carbon emissions and promoting renewable energy. By using eco-friendly materials and energy-efficient design, the dome will not only minimize environmental impact but also serve as a model for sustainable development in the region. The outcome is presented in the local highschool journal as a scientific research paper.
AI/ML, Engineering, Computer Science, Business
The significance of native biomolecules in the tumor microenvironment
This interesting project will investigate and seek to find the chemicals found in tumors, why they are there and how they affect the tumor cell population. This project will provide a sound understanding of the nature of oncology.
Cancer
The role of Macrophages and Class Switching in the Tumor Microenvironment
This project would go into cellular detail of the role macrophages, an immune cell plays in the initiations, development and metastasis of cancers. This project will also explore how immunomodulators can effect a chance on the role immune cells play in the tumor microenvironment in resistance, fibrosis, evasion and cytotoxicity. This project will provide state-of-art insights into immunotherapies and immune cell genetics
Cancer