Mahima Balakrishnan

How does genetic hybridization (via mating/mixing of species) affect the vocalization genes in birds? How can that provide new approaches for human speech therapy?

Started June 10, 2024

Abstract or project description

The study of bird vocalizations, in particular songs and calls, highlight its significance for survival and the variety in expression. Key vocalization genes in birds, such as FOXP1 and FOXP2, have a significant influence on neural circuits, regulatory networks, and the maturation of brain regions responsible for vocal learning and the production of sound. Genetic hybridization is used to analyze genetic makeup and specific changes in the expression of vocalization genes in birds. Understanding the genetic underpinnings of bird vocalization serves as a key way to assess their potential implications for human speech therapy. A comparative analysis of bird and human vocalization genes reveals similarities in genetic pathways and functionality, particularly with FOXP1 and FOXP2 expression, as well as differences in gene regulation and expression. These research findings can be utilized to identify common speech and language disorders and improve human speech therapy. Additionally, this paper looks at the role of CRISPR technology in improving speech therapy, as well as the ethical concerns and potential challenges raised by doing so, providing a comprehensive overview of this interdisciplinary field.