How does genetic hybridization (via mating/mixing of species) affect the vocalization genes in birds? How can that provide new approaches for human speech therapy?

Project by Polygence alum Mahima

How does genetic hybridization (via mating/mixing of species) affect the vocalization genes in birds? How can that provide new approaches for human speech therapy?

Project's result

Research Paper

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Summary

The study of bird vocalizations, in particular songs and calls, highlight its significance for survival and the variety in expression. Key vocalization genes in birds, such as FOXP1 and FOXP2, have a significant influence on neural circuits, regulatory networks, and the maturation of brain regions responsible for vocal learning and the production of sound. Genetic hybridization is used to analyze genetic makeup and specific changes in the expression of vocalization genes in birds. Understanding the genetic underpinnings of bird vocalization serves as a key way to assess their potential implications for human speech therapy. A comparative analysis of bird and human vocalization genes reveals similarities in genetic pathways and functionality, particularly with FOXP1 and FOXP2 expression, as well as differences in gene regulation and expression. These research findings can be utilized to identify common speech and language disorders and improve human speech therapy. Additionally, this paper looks at the role of CRISPR technology in improving speech therapy, as well as the ethical concerns and potential challenges raised by doing so, providing a comprehensive overview of this interdisciplinary field.

Riya

Riya

Polygence mentor

MD Doctor of Medicine candidate

Subjects

Literature, Biology

Expertise

Molecular Biology, Cellular Biology, Genetics, Psychology, Sociology, English, Religious Studies, Theology, Philosophy, Indian Classical Dance (Bharatnatyam, Kuchipudi, Odissi), Cultural Studies

Mahima

Mahima

Student

Graduation Year

2025

Project review

“I was able to get a lot of guidance and mentorship to help me write a good research paper. I really enjoyed working on this and believe that this was a wonderful experience for me.”

About my mentor

“Super flexible and a great listener. She understands the structure of research papers really well and has many resources that she provides.”