Vidushi Agrawal

Anti-Cancer Properties of Medicinal Plants/Fungi

Started Dec. 27, 2023

Abstract or project description

This paper aims to explore the anti-cancer potential of natural compounds derived from three distinct plants: Camptotheca acuminata (CA), Andrographis paniculata (AP), and Agaricus blazei Murill (AbM). Each plant offers unique mechanisms for combating cancer, ranging from well-established DNA-damaging agents to novel immunomodulatory compounds. CA has long been recognized for its potent anti-tumor agent, camptothecin (CPT), and its clinically used derivatives, topotecan and irinotecan, which target DNA topoisomerase I and interfere with DNA replication. AP and its primary bioactive compound, andrographolide, exhibit multi-targeted anti-cancer activities, including apoptosis induction, cell cycle arrest, inhibition of metastasis, and immune system enhancement. AbM leverages beta-glucans and other bioactive compounds to modulate the immune system, promote apoptosis, and exhibit anti-inflammatory properties. This paper compares and contrasts these plants in terms of their historical use, research progression, mechanisms of action, clinical applications, and potential future research directions. While CA derivatives are already integral to cancer treatment protocols, AP and AbM are emerging as promising candidates that warrant further clinical investigation. The research on CA has established its efficacy and tolerability through extensive clinical trials, leading to its widespread use. In comparison, AP and AbM are still in the early stages of clinical research but show significant potential due to their diverse mechanisms of action and lower toxicity profiles. The comprehensive analysis presented in this paper aims to highlight the diverse therapeutic possibilities offered by these natural compounds and their potential to enhance current cancer treatment modalities. With further research, these therapies could significantly impact disease progression and improve patient outcomes in the fight against cancer.