Sarah Wang

Factors influencing the rate of clinical deterioration in Parkinson's disease: a multi-factorial review

Started June 3, 2023

Abstract or project description

Parkinson's disease is one of the most prominent and devastating neurodegenerative disorders worldwide. However, each PD patient has a unique disease course due to individual variation in the rate of cognitive and psychomotor decline. In this review article, we will analyze factors influencing such individual variation and the amount of concrete information we currently have on PD. We will focus particularly on genetic factors, social/socioeconomic factors, and medical comorbidities using existing data and information gathered from previous experiments. We will discuss the implications such factors should have on treatment options and disease management and the effects the COVID-19 pandemic had on PD patients.