Sahasra B

The fundamental role of dietary habit, physical activity, and sleep pattern on Amyloid-beta and Tau pathology.

Started Feb. 5, 2024

Abstract or project description

Alzheimer’s disease (AD) is a debilitating neurodegenerative disease that affects an estimated 24 million adults over the age of 65 worldwide, with symptoms including memory loss, cognitive decline, and behavioral changes. Currently, there is no cure, although there is a 100% mortality rate once the disease has progressed. Age is the most significant risk factor for developing AD; however, diet, physical activity, and disrupted sleep patterns contribute to disease progression. An improper diet, in particular, can contribute to inflammation and increase reactive oxygen species, leading to AD progression. Physical activity has many benefits on overall health but has a unique positive impact on AD through improved cognitive outcomes. Sleep disturbances are regularly reported by AD patients. There is now evidence to support sleep disruption as an early marker of AD while also significantly contributing to the progression of AD. Improving diet, physical activity, and sleep patterns may have positive outcomes for AD patients and reduce the burden on their families and caretakers, promoting a healthier family environment. In this review, we will explore how diet, physical activity, and sleep patterns contribute to AD progression and highlight how changes in these areas can improve the quality of life of AD patients.