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Grant Murphy
Class of 2025Los Gatos, CA
About
Projects
- "Wild Type Oncolytic Viruses as a Means for Facilitating Antitumor Immune Response" with mentor Zachary (Oct. 11, 2023)
Project Portfolio
Wild Type Oncolytic Viruses as a Means for Facilitating Antitumor Immune Response
Started June 26, 2023
Abstract or project description
Grant will also write a paragraph, but here is the basic outline for the research article:
Introduction
Categories of Wild Type OVs -table: table listing many viruses
Challenges for Wild Type OVs -safety (attenuation) -efficacy -AEs -Figure: virus split in half, one half shows safety challenges, other shows efficacy challenges
Wild Types OVs affecting the TME -cell types (pro tumor immune cells, anti tumor immune cells, fibroblasts, endothelial cells)
Figure: visual of the TME and how each cell type is affected by OVs Combination Therapy: -ICIs -chemo -radiation -other immunotherapies (CARs, BITEs) -Targeted therapy/ small molecule inhibitors -table of clinical trials regarding these combinations (clinicaltrial.gov) -figure demonstrating how a interesting combination works
Conclusion