Emel Çırakoğlu | Polygence
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Polygence Scholar2023
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Emel Çırakoğlu

Class of 2022Ankara, Ankara

About

**Hi! My name is Emel. My project is about biomarkers that can detect MS in early stages and gene therapies that can be used as a treatment approach in the future.**

Projects

Project Portfolio

Gene Therapy With CRISPR-Cas9 To Treat Multiple Sclerosis

Started June 20, 2023

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Abstract or project description

Multiple Sclerosis (MS) is a chronic immune-mediated neurodegenerative disease leading to progressive demyelination and atrophy in the brain. This project aims to first briefly highlight immune mediators of the disease, especially regulatory T cells (Tregs). The project will then discuss biomarkers associated with MS, focusing on those expressed by Tregs. Subsequently, the CRISPR-Cas9 system and how it targets genes for deletion, insertion, or replacement will be described. The final part of the project will discuss different targets and delivery methods for CRISPR-Cas9 therapy for MS.