Elle Scord

Molecular mechanisms of different tauopathies

Started Jan. 19, 2024

Abstract or project description

Tauopathies, a division of neurodegenerative diseases defined by the deposition and aggregation of abnormal tau protein, include a diverse array of conditions that pose a relevant and withstanding concern in neurobiology and medicine. While associated tauopathies may share similar pathological features such as the abnormal accumulation of tau protein, they differ in their clinical presentation, molecular mechanisms, and neuropathological patterns. Thus, highlighting the similarities and differences in the isoform specific variations and the molecular pathology of tauopathies is crucial for understanding and advancing knowledge in the field. This review will specifically outline the important molecular characteristics of Alzheimer's Disease (AD), Progressive Supranuclear Palsy (PSP), and Chronic Traumatic Encephalopathy (CTE) identifying their neuropathology, dominant isoform significance, post-translational modifications, and cellular response. Thus, this review aims to provide a detailed analysis of the current knowledge surrounding tauopathies, highlight areas for future research, and emphasize the broader implications for the field of neurodegenerative disease. With enhanced comprehension of the mechanisms that underlie these diseases, diagnostic measures, potential biomarkers, treatments, and preventions may be improved through identifying unifying characteristics. Conversely, understanding the molecular differences of tauopathies may not only enhance our understanding of these diseases, but also differential treatment mechanisms specific to the tauopathy.