Chhavi Pokharna

What molecular mechanisms underlie the transformation of astrocytes and their role in the pathogenesis of neurodegenerative disorders?

Started June 3, 2023

Abstract or project description

Neurodegenerative disorders pose a significant and growing burden on global healthcare systems, necessitating a comprehensive understanding of their pathogenesis in order to develop effective therapeutic interventions. Among the various cell types, astrocytes, a type of glial cell, have emerged as important players in neurodegenerative disorders. This research investigates the molecular mechanisms driving the transformation of astrocytes and their role in the pathogenesis of neurodegenerative disorders. The context of this article lies in the escalating prevalence of these disorders, including but not limited to: Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis (ALS), which significantly impact patients' cognitive and motor functions. This research addresses the central question of the specific molecular changes that trigger the transformation of astrocytes and how these altered astrocytes contribute to the initiation and progression of neurodegenerative disorders. Previous research has provided insights into the involvement of astrocytes in neurodegenerative disorders, showing that reactive astrogliosis occurs in response to neuronal damage, leading to altered astrocyte functions. However, the precise molecular mechanisms driving this transformation and the following consequences on neurodegenerative pathogenesis remain understudied. By exploring the molecular changes in astrocytes and their impact on neurodegeneration, this study aims to fill a critical gap in current knowledge and potentially identify therapeutic targets. Understanding the molecular basis of astrocyte transformation could offer new opportunities for intervention and lead to the development of more precise and effective treatments for neurodegenerative disorders. Ultimately, these findings could lead to improved patient outcomes and enhance the quality of life for those affected by neurodegenerative disorders. Moreover, this research may also inspire further investigations into the complex interplay between astrocytes and neurons, providing a foundation for future studies aiming to uncover additional therapeutic opportunities in the fight against neurodegeneration.