Charlotte Tang

What are the epigenetic contributors to cancer, and how does epigenetics affect cancer progression?

Started May 2, 2024

Abstract or project description

This research paper will focus on epigenetics, or changes to the genome that do not change the DNA sequence, but can nonetheless influence gene expression and protein function. One form of epigenetic modification that will be considered in histone acetylation. Acetylation is generally a mark for open euchromatin that is more transcriptionally active, and is regulated through the action of histone acetyltransferases (HATs) and histone deacetylases (HDACs). The balance of these proteins can become misregulated in cancer, and the research paper will explore this process, as well as more general trends in epigenetics in cancer progression. Finally, the paper may consider how to leverage knowledge on epigenetics to achieve more effective cancer treatment, such as through the action of HDAC inhibitor drugs, which are often used in the clinic today.