Atrey Wadikar

Bioinformatics analysis of the NFkB pathway in brain tumors

Started Mar. 18, 2024

Abstract or project description

Cancer has been a big field of research. Much research has been put into the cure of cancer. One of such genes that play an important role in cancer research is the NF-kB pathway. My project will be going over NFKB genomics, such as NFKB1 and NFKB2, and how they are potent against tumor cells. My project focuses on brain tumors such as Glioblastoma Multiforme and Low-Grade Gliomas, (GBM and LGG). My research tackles the question on how the expression of NFKB in patients of GBM and LGG has an effect on their prognosis. The research of the NFKB gene on GBM and LGG could be helpful for future research. I chose these two tumors because GBM is a fatal cancer while LGG having a high prognosis rate has the same trend as GBM. All the data has been collected from public datasets like GlioVis, R2: Genomics, cBioPortal etc. These datasets are expressions of NFKB and a Kaplan-Meier estimator survival analysis chart for both GBM and LGG. The results indicate how the higher expression of NFKB gives a better survival edge compared to low NFKB expression in both the tumors and both NFKB1 and NFKB2 genes. In conclusion, research of NFKB has been instrumental in understanding cancer progression especially in this day and age of modern biotechnology.