Anika Chakrabarti

How is the dysregulation of epigenetic mechanisms linked to neurological disorders (Huntington’s, Alzheimer’s)?

Started Feb. 2, 2024

Abstract or project description

Epigenetics, with its diverse mechanisms such as DNA methylation, histone acetylation, and ncRNAs, holds significant therapeutic potential for a wide range of disorders and diseases. Its intrinsic adaptability prevents DNA from enduring permanent damage while at the same time, regulating gene expression in reversible and plastic ways. It is a natural and dynamic process that needs continuous regulation for our bodies to function properly. However, this essential machinery can be disrupted by various factors. This paper will explore the molecular and cellular changes that occur in the brain due to epigenetic dysregulation, and how these changes are correlated to neurodegenerative diseases such as Alzheimer's and Huntington’s disease.