In what ways can the interconnections between the gut microbiome and the brain influence Alzheimer's disease susceptibility and progression?

Alzheimer's disease is a neurodegenerative disorder that causes memory decline over time. The human gut is colonized with millions of microscopic organisms that can communicate with the brain. Recently research has established a gut-brain axis between these two organs, and this communication link has been implicated in neurodegenerative diseases such as Alzheimer's disease. Given the mounting evidence that the gut-brain axis impacts Alzheimer’s disease progression, the gut brain-axis may also have therapeutic potential. In this review, we discuss recent research that highlights the impact of the gut microbiome on Alzheimer’s disease using mouse models and human fecal samples. We hope that increased knowledge of the gut-brain axis expands our understanding of Alzheimer's disease and leads to the advancement of future treatments.